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Genes (Impact Factor 3.759, Q2) published an article by the FSBI RCMG researchers

Preferentially Paternal Origin of de novo 11p13 Chromosome Deletions Revealed in Patients with Congenital Aniridia and WAGR Syndrome

Tatyana A. Vasilyeva, Andrey V. Marakhonov, Natella V. Sukhanova, Sergey I. Kutsev and Rena A. Zinchenko.

In patients with congenital aniridia and WAGR syndrome, the predominantly paternal origin of alleles with de novo chromosomal deletions has been proven.

Similarity of the authors’ findings with those in the earlier published paper confirms this pattern. The authors assumed that a shift in distribution of de novo deletions origin on maternal and paternal alleles might be due to the time of occurrence of the deletion and/or differential pattern of this locus methylation in the paternal and maternal gametogenesis or in the early postzygothic period.

Genes 2020, 11(7), 812.