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The 44th European Cystic Fibrosis Congress culminated in Milan

The 44th European Cystic Fibrosis Congress, which took place on a digital platform from June 9 to 12, 2021, culminated in Milan. More than 2,000 attendees from 57 countries participated in the Congress. The program of the Congress included sessions on genetics, microbiology, new approaches to the diagnosis and therapy of cystic fibrosis and its complications. The FSBI RCMG researchers actively participated in the Congress having made 14 presentations, of which five were reporter's reports.

Professor E.I. Kondratieva et al. in her report focused on the changes in the number of copies of ribosomal genes in the genomes of cystic fibrosis patients. The report of T.A. Adian gave the description of newly identified pathogenic variants of the CFTR gene. O.G. Novoselova described the genetic variability of enzyme genes involved in xenobiotic metabolism and the risk of nasal polyps in patients with cystic fibrosis. E.K. Zhekaite's presentations addressed liver cirrhosis and liver transplantation in cystic fibrosis patients in the Russian Federation (a joint report of Cystic Fibrosis Department with FSBI Academician V.I. Shumakov National Medical Research Center for Transplantology and Artificial Organs), and the creation of a model determining the risk of vitamin D deficiency in children with cystic fibrosis and prevention algorithm.

In addition to oral presentations, some research by the RCMG staff were presented in the poster session. These included the report by Yu.L. Melyanovskaya on "soft" genetic variants in the CFTR gene, posters by S.I. Kutsev and E.I. Kondratieva devoted to the 30th anniversary of cystic fibrosis patients' care in Russia, and E.I. Kondratieva on specific features of coronavirus infection in children with cystic fibrosis in Russia, and also a joint poster by V.V. Shadrina and E.I. Kondratieva on the age and genotype effect on the lung function in children with cystic fibrosis. The following presentations were made in co-authorship with researchers of N.F. Gamaleya Institute - L.R. Avetisyan and M.Yu. Chernukhi: On microevolution of Pseudomonas aeruginosa in lungs of patients with cystic fibrosis and on mutations in chromosome genes of T3SS strains of Pseudomonas aeruginosa, isolated from lungs of patients with cystic fibrosis. N.V. Petrova prepared a poster about the complex allele [F508del; L467F]; N.Yu. Kashirskaya and her co-authors from the Registry organizing committee prepared a poster report on the indicative trends in the national cystic fibrosis Registry in the Russian Federation in 2011-2019. S.A. Krasovsky in co-authorship with A.V. Chernyak prepared a report on the method of nitrogen washout in multiple breathing and lung lesions in adult patients with cystic fibrosis.