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A Joint Article Devoted to the Complex Spermatological Examination of Men With Pulmonary and Mixed Forms of Cystic Fibrosis Was Published By the Stuff of the Reproduction Disorders Genetics Laboratory at RCMG

Employees of the laboratory of reproduction disorders genetics together with scientific clinical department for cystic fibrosis and laboratory of DNA-diagnostics at RCMG published article «Complex Spermatological Research of Men With Pulmonary and Mixed Forms of Cystic Fibrosis» in the “Asian Journal of Andrology” (IF 3,285).

Cystic fibrosis is a common monogenic autosomal recessive disease caused by pathogenic variants of the CFTR gene, which are common genetic factors of male infertility. According to literature, about 98% of male patients with cystic fibrosis are infertile due to obstructive azoospermia.

A cohort study of 93 male patients found that most cystic fibrosis patients were infertile due to obstructive azoospermia, and only in 62 men with pathogenic variant 3849+10kbC>T of CFTR gene was found that their seedbed pathways were still passable. The researchers identified various spermatological disorders without azoospermia and severe oligozoospermia, and without the predominance of any form of gamete atypia.

Follow the link to read the full text of the article: Anna O Sedova, Maria I Shtaut, Elizaveta E Bragina, Tatyana M Sorokina, Galina V Shmarina, Marina V Andreeva, Lyubov F Kurilo, Stanislav A Krasovskiy, Aleksander V Polyakov, Vyacheslav B Chernykh. Comprehensive Semen Examination in Patients with Pancreatic-sufficient and Pancreatic-insufficient Cystic Fibrosis. Asian Journal of Andrology (2023) 25, 1–7.