Genogeography of LZTFL1 Gene Markers Associated with COVID-19 Heavy Current

The human genetics laboratory at RCMG investigated the spatial variability of SNP markers of the LZTFL1 gene associated with the severe course of COVID-19 coronavirus infection.

 The LZTFL1 gene in clinical studies has been associated with a two-fold increase in the risk of severe coronavirus COVID-19 infection. Scientists have studied the spatial variability of SNP-markers of LZTFL1 gene in the indigenous population of Russia and the world, and have analyzed the spatial variability of polymorphic markers of LZTFL1 gene in 28 meta-populations (97 ethnos) of Northern Eurasia and 34 meta-populations of the world. It is found that in Northern Eurasia the main geographical vectors of variability «north-south» and «west-east» are generally consistent with the anthropological vector «Caucasoid-Mongoloid». The main vector of global variability corresponds to the anthropological division of the world’s population. Clusters of indigenous people in Africa, Asia and the Americas include only the «own» part of the world, and the «Indo-European» cluster - Caucasian populations in both Europe and Asia.

Geneticists have created a map atlas of spatial variability of 11 SNP-markers of the LZTFL1 gene in the population of North Eurasia and the world, showing that the world’s extremes of variability occur among the indigenous populations of Africa and America. It was revealed that Eurasia is a transitional zone between these two extremes and has its own patterns, and the genetic landscape of Russia is organically inscribed in the Eurasian landscape.

Balanovskaya E.V., Gorin I.O., Petrushenko V.S., Chernevsky D.K., M. Koshel S.M., Temirbulatov I., Pylyov V. Y., Agjoyan A.T. Gene Geography in Russia and in the World of SNP-markers of LZTFL1 Gene Associated with COVID-19 Heavy Current//Bulletin of RSMU, #5, DOI: 10.24075/vrgmu.2022.047.

For more details follow the link: https://vestnik.rsmu.press/archive/2022/5/4/abstract?lang=ru