Publication in Molecular Biology Reports journal
Molecular Biology Reports (IF 2.107, Q3) published an article by the researchers of the Genome Editing Laboratory (the Lab Head is S. A. Smirnikhina, Candidate of medical science):
TIRR – a potential front runner in HDR race: hypotheses and perspectives
Anuchina A.A., Lavrov A.V., Smirnikhina S.A.
The low efficiency problem of genomic editing by means of homologous recombination is relevant for some research groups dealing with this topic around the world. TIRR protein capable of binding to 53BP1 protein, which is a key participant in the process of non-homologous connection of the ends (NHEJ), has been recently discovered. TIRR protein can interfere with 53BP1 involvement in double-stranded break repair. A number of studies have revealed molecular mechanisms for TIRR and 53BP1 proteins interaction. Overexpression of TIRR was shown to contribute to the restoration of double-stranded DNA breakage by homologous recombination.
The conclusions allow us to consider the TIRR protein to be a suitable target for increasing the efficiency of genomic editing using homologous recombination.