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Article in Cells Journal

Cells journal (IF 4.829, Q1) published the results of the researchers’ study of the FSBI RCMG Laboratory of Genetics of Reproductive Disorders:

The Centriolar Adjunct–Appearance and Disassembly in Spermiogenesis and the Potential Impact on Fertility

Garanina AS, Alieva IB, Bragina EE, Blanchard E, Arbeille B, Guerif F, Uzbekova S, Uzbekov RE..

Cells. 2019; 8(2):180.

For the first time, the structure of the centriolar adjunct (CA) in the cell, and its consequent impact on male fertility, were examined. We showed that in humans, the centriolar adjunct remnants are present in a fraction of mature spermatids and disappears completely in mature porcine spermatozoa.CA was significantly longer in the spermatozoa of IMS patients than in the spermatozoa of healthy donors. This difference was independent of chromatin condensation deficiency, which was also observed in the spermatozoa of IMS patients. We suggest that zygote arrest may be related to an incompletely disassembled centriolar adjunct in a mature spermatozoon. Therefore, centriolar adjunct length can be potentially used as a complementary criterion for the immaturity of spermatozoa in the diagnostics of IMS patients.