Publication in Biomedicines journal

Biomedicines (impact-factor 3.331, ScopusQ1) published an article by the researchers of the FSBI RCMG Epigenetics Laboratory (headed by Strelnikov V.V., Doctor of biological science):

Abnormal Hypermethylation of CpG Dinucleotides in Promoter Regions of Matrix Metalloproteinases Genes in Breast Cancer and its Relation to Epigenomic Subtypes and HER2 Overexpression

Olga A. Simonova,Ekaterina B. Kuznetsova ,Alexander S. Tanas,Viktoria V. Rudenko,Elena V. Poddubskaya,Tatiana V. Kekeeva,Ivan D. Trotsenko,Sergey S. Larin,Sergei I. Kutsev,Dmitry V. Zaletaev,Marina V. Nemtsova &Vladimir V. Strelnikov 

Methylation of genes encoding matrix metalloproteinases in surgical breast cancer samples was studied. Metalloproteinase genes are of interest due to the estimated probability of tumor metastases development.

Anomalous methylation of some metalloproteinase genes associated with HER2-positive breast cancer has been detected. The study showed that abnormal methylation of was tumor-specific and reflected the belonging of specific tumors to the hyper-methylated subtype of breast cancer.

Biomedicines 2020, 8(5), 116; https://doi.org/10.3390/biomedicines8050116
Received: 16 April 2020 / Revised: 6 May 2020 / Accepted: 8 May 2020 / Published: 10 May 2020