Article in Epigenomics journal
Genome-wide methylotyping resolves breast cancer epigenetic heterogeneity and suggests novel therapeutic perspectives».
Authors: Alexander S Tanas, Vladimir O Sigin, Alexey I Kalinkin, Nikolai V Litviakov, Elena M Slonimskaya, Marina K Ibragimova, Ekaterina O Ignatova, Olga A Simonova, Ekaterina B Kuznetsova, Tatiana V Kekeeva, Sergey S Larin, Elena V Poddubskaya, Ivan D Trotsenko, Viktoria V Rudenko, Kristina O Karandasheva, Kseniya D Petrova, Matvey M Tsyganov, Irina V Deryusheva, Polina V Kazantseva, Artem V Doroshenko, Natalia A Tarabanovskaya, Galina G Chesnokova, Marina I Sekacheva, Marina V Nemtsova, Vera L Izhevskaya, Sergey I Kutsev, Dmitry V Zaletaev & Vladimir V Strelnikov
“Characteristics of breast cancer epigenetic heterogeneity and the development of new therapeutic approaches based on a wide genome methylation analysis”.
The aim was to provide an epigenetic classification of breast cancer (BC) subtypes. According to the results of the wide-genome bisulfite sequencing of gene promoters conducted by the XmaI-RRBS method, two superclusters of BC samples were identified; they were highly methylated and moderately methylated. Each of them, in turn, contained three epigenomic subtypes with unique properties, the study of which allows us to propose new approaches to personalized BC therapy.