Article in Oxidative Medicine and Cellular Longevity Journal
Oxidative Medicine and Cellular Longevity Journal (impact-factor 4,936, Q1) published an article by researchers of the Molecular Biology Laboratory (headed by Kostyuk S.V., Doctor of biological science), FSBI RCMG, in co-authorship with Institute of Problems of Chemical Physics of RAS and Skolkovo Innovation Center:
«Antioxidant properties of fullerene derivatives depend on their chemical structure: a study of two fullerene derivatives on HELFs».
Vasilina Sergeeva, Olga Kraevaya, Elizaveta Ershova, Larisa Kameneva, Elena Malinovskaya, Olga Dolgikh, Marina Konkova, Iliya Voronov, Alexander Zhilenkov, Natalia Veiko, Pavel Troshin, Sergei Kutsev, and Svetlana Kostyuk
«Antioxidant properties of fullerene derivatives depend on their chemical structure: a study of two fullerene derivatives on human embryonic lung cells».
Oxidative stress is a major issue in a wide number of pathologies (neurodegenerative, cardiovascular, immune diseases, and cancer). Because of this, the search for new antioxidants is an important issue. One of the potential antioxidants that has been enthusiastically discussed in the past twenty years is fullerene and its derivatives. We have studied two different water-soluble fullerene C60 and C70 derivatives on human embryonic lung fibroblasts at a wide range of concentrations. Both of them cause a decrease in cellular ROS at short times of incubation (1 hour). Their prolonged action, however, is fundamentally different: derivative GI-761 causes secondary oxidative stress whereas derivative VI-419-P3K keeps ROS levels under control values. To gain a better understanding of this effect, we assessed factors that could play a role in the response of cells to fullerene derivatives. The data obtained during the study suggests that the antioxidant effect of fullerene derivatives depends on their chemical structure.