Publication in Frontiers in Cell and Developmental Biology journal
Frontiers in Cell and Developmental Biology (IF 5.206, Scopus Q1) published an article by the researchers of the FSBI RCMG Molecular Biology Laboratory (headed by S.V. Kostyuk, Doctor of biological science) who for the first time published data on the influence of large domain 1q12 on the chromatin movement and adaptive response inhibition.
1Q12 Loci Movement in the Interphase Nucleus under the Action of ROS Is an Important Component of the Mechanism That Determines Copy Number Variation of Satellite III (1q12) in Health and Schizophrenia
Marina Sergeevna Konkova, Elizaveta Sergeevna Ershova, Ekaterina Alekseevna Savinova, Elena Mikhailovna Malinovskaya, Galina Vasilievna Shmarina, Andrey Vladimirovich Martynov, Roman Vladimirovich Veiko, Nataly Vyacheslavovna Zakharova, Pavel Umriukhin, Georgy Petrovich Kostyuk, Vera Leonidovna Izhevskaya, Sergey Ivanovich Kutsev, Natalia Nikolaevna Veiko and Svetlana Victorovna Kostyuk.
It is known that the size of clusters of repeating genome regions affect the spatial configuration and function of chromatin. Low-dose ionizing radiation induces an adaptive response in human cells. The adaptive response includes changes in spatial configuration of chromatin, which is necessary to change the profile of genome expression in response to stress. The movement of 1q12 heterochromatin loci from the periphery to the nucleus center is a marker of chromatin configuration changes. For the first time data on the influence of large 1q12 domain on chromatin movement and inhibition of adaptive response have been published. A study of the effect of large 1q12 on chromatin movement and adaptive response inhibition has shown that large 1q12 domains do not move in response to stress. During prolonged cultivation, irradiated cells with large 1q12 cluster size die, and cells with low 1q12 cluster area enrich the population. It has been experimentally proven that patients with schizophrenia have a low repetition content of 1q12 in genomes, which may be a consequence of chronic oxidative stress and a large number of ribosomal gene copies.
Front. Cell Dev. Biol., 05 June 2020 | https://doi.org/10.3389/fcell.2020.00386