Research Centre for Medical Genetics
1 Moskvorechye St,
Moscow 115522, Russian Federation
Mo-Fr: 9:00 - 17:00
Reception
+7 (495) 111-03-03
Рус
What would you like to find?

Data on the Increased Number of Copies of Ribosomal Genes in the Genomes of Schizophrenia Published by RCMG for the Caucasian Population, Reproduced by Japanese Scientists

In PlosOne magazine, on January 20, 2023, authors from Japan (Kobe University Graduate School of Medicine, Kobe, Japan) published an article that reported an increased number of copies of ribosomal genes in the genomes of Asian schizophrenia.

The key goal of the work, declared by the Japanese authors, was to reproduce experimental data, given in three, quoted by the authors, articles of the laboratory of molecular biology at RCMG:

  1. Veĭko NN, Egolina NA, Radzivil GG, Nurbaev SD, Kosiakova NV, Shubaeva NO, et al. [Quantitative analysis of repetitive sequences in human genomic DNA and detection of an elevated ribosomal repeat copy number in patients with schizophrenia (the results of molecular and cytogenetic analysis)]. Mol Biol (Mosk). 2003;37:409–19.
  2. Chestkov IV, Jestkova EM, Ershova ES, Golimbet VE, Lezheiko TV, Kolesina NY, et al. Abundance of ribosomal RNA gene copies in the genomes of schizophrenia patients. Schizophr Res. 2018;197:305–14. pmid:29336872
  3. Ershova ES, Malinovskaya EM, Golimbet VE, Lezheiko TV, Zakharova NV, Shmarina GV, et al. Copy number variations of satellite III (1q12) and ribosomal repeats in health and schizophrenia. Schizophr Res. 2020;223:199-212. pmid:32773342 https://ww.sciencedirect.com/science/article/pi/S0920996420304151?via3Dihub

The results obtained by authors from Japan for the Asian schizophrenic and healthy population fully corroborate earlier data for the Caucasian population: The number of copies of ribosomal genes in the genomes of blood leukocytes with schizophrenia is reliably higher than the number of copies in the genomes of mentally healthy people who do not suffer other hereditary pathology.

The full text of the publication can be found at:

Li S, Otsuka I, Tanifuji T, Okazaki S, Horai T, Takahashi M, et al. (2023) Ribosomal DNA gene copies are increased in blood and brain of Japanese schizophrenia patients. PLoS ONE 18(1): e0280694.  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0280694