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HEAD
Doctor of biological science, Professor |
RESEARCH TEAM: The Laboratory staff Andrey A. Alimov, Leading researcher, Candidate of biological science, PhD, Doctor of Medicine Eleonora A. Braga, Leading researcher, Candidate of biological science, Professor Tatiana A. Muzaffarova, Senior researcher, Candidate of medical science Aleksandra A. Korotaeva, – Senior researcher, Candidate of medical science Vitaly I. Loginov, Senior researcher, Candidate of biological science Natalia V. Apanovich, researcher, Candidate of medical science Pavel V. Apanovich, researcher Fatimat M. Kipkeeva, researcher Anna Y. Kuzevanova, researcher Kristina A. Grishina, research trainee Danzan Z. Mansorunov , research assistant |
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CONTACT INFORMATION:
Tel.: +7 (499) 324-12-39; +7 (499) 612-98-49; +7 (499) 612-79-59 |
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The Laboratory focuses on the study of structural and functional characteristics of genes and molecular mechanisms for the diseases of complex genetic etiology, mainly oncological; the development of new drugs for cancer therapy, methods of diagnosis and individualized therapy
The Laboratory was the first to study the spectra and mutation rates in the genes predisposed to socially significant cancer among Russian patients, for example, breast and ovarian cancer, colorectal cancer, familial adenomatous polyposis, gastric cancer, cancer of the uterus, etc. They developed some methods for diagnosing susceptibility to cancer of many localizations, and a great deal of practical diagnostics experience has been gained.
The Laboratory analyses the influence of functional features of genes and miRNA on a cancer tumor development. It obtained new data on the relationship of gene expression with cancer progression, survival characteristics and response to drug exposure; developed ways to individualize cancer therapy, increase the effectiveness of treatment, and reduce its toxicity
A new medication was developed for colon cancer therapy on the most modern basis - small interfering RNA. The preclinical studies have demonstrated its high efficiency and low toxicity, immunogenicity and mutagenicity.
Contact information:
Address: 115478, Moscow, ul. Moskvorechie Str., 1
Tel.: +7 (499) 324-12-39; +7 (499) 612-98-49; +7 (499) 612-79-59
Fax: +7 (495) 324-07-02
Е-mail: brca1@mail.ru; karpukhin@med-gen.ru
Contact information
+7 (495) 111-03-03
(multichannel)