Structure
Laboratory of molecular genetics of complex inherited diseases

http://www.med-gen.ru/docs/karpuhin.jpg

HEAD
Aleksandr V. Karpukhin
Head of the Laboratory

Doctor of biological science, Professor
karpukhin@med-gen.ru
Details:

RESEARCH TEAM:

The Laboratory staff

Andrey A. Alimov, Leading researcher, Candidate of biological science, PhD, Doctor of Medicine

Eleonora A. Braga, Leading researcher, Candidate of biological science, Professor

Tatiana A. Muzaffarova, Senior researcher, Candidate of medical science

Aleksandra A. Korotaeva, – Senior researcher, Candidate of medical science

Vitaly I. Loginov, Senior researcher, Candidate of biological science

Natalia V. Apanovich, researcher, Candidate of medical science

Pavel V. Apanovich, researcher

Fatimat M. Kipkeeva, researcher

Anna Y. Kuzevanova, researcher

Kristina A. Grishina, research trainee

Danzan Z. Mansorunov , research assistant

CONTACT INFORMATION:
Address: 115478, Moscow, ul. Moskvorechie Str., 1

Tel.: +7 (499) 324-12-39; +7 (499) 612-98-49; +7 (499) 612-79-59
Fax: +7 (495) 324-07-02
Е-mail: brca1@mail.rukarpukhin@med-gen.ru

Main publications:

Theses defended:

The Laboratory focuses on the study of structural and functional characteristics of genes and molecular mechanisms for the diseases of complex genetic etiology, mainly oncological; the development of new drugs for cancer therapy, methods of diagnosis and individualized therapy

            The Laboratory was the first to study the spectra and mutation rates in the genes predisposed to socially significant cancer among Russian patients, for example, breast and ovarian cancer, colorectal cancer, familial adenomatous polyposis, gastric cancer, cancer of the uterus, etc. They developed some methods for diagnosing susceptibility to cancer of many localizations, and a great deal of practical diagnostics experience has been gained.

            The Laboratory analyses the influence of functional features of genes and miRNA on a cancer tumor development. It obtained new data on the relationship of gene expression with cancer progression, survival characteristics and response to drug exposure; developed ways to individualize cancer therapy, increase the effectiveness of treatment, and reduce its toxicity

            A new medication was developed for colon cancer therapy on the most modern basis - small interfering RNA. The preclinical studies have demonstrated its high efficiency and low toxicity, immunogenicity and mutagenicity.

Contact information:

Address: 115478, Moscow, ul. Moskvorechie Str., 1

Tel.: +7 (499) 324-12-39; +7 (499) 612-98-49; +7 (499) 612-79-59

Fax: +7 (495) 324-07-02

Е-mail: brca1@mail.ru; karpukhin@med-gen.ru